CDH12 polyclonal antibody
产品名称： CDH12 polyclonal antibody
英文名称： CDH12 polyclonal antibody
产品编号： PAB3137
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CDH12.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CDH12.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.
Shimoyama Y, Tsujimoto G, Kitajima M, Natori M.Biochem J. 2000 Jul 1;349(Pt 1):159-67.
- 2.
- Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma.
Chalmers IJ, Hofler H, Atkinson MJ.Genomics. 1999 Apr 1;57(1):160-3.
- 3.
- Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.
Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF.Genomics. 1998 May 1;49(3):467-71.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of CDH12 polyclonal antibody (Cat # PAB3137) in 293 cell line lysates (35 ug/lane). CDH12 (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human brain tissue reacted with CDH12 polyclonal antibody (Cat # PAB3137) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 1010
- Protein Accession#:
- NP_004052;P55289
- Gene Name:
- CDH12
- Gene Alias:
- CDHB,FLJ34857
- Gene Description:
- cadherin 12, type 2 (N-cadherin 2)
- Omim ID:
- 600562
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq
- Other Designations:
- Br-cadherin,N-cadherin 2,OTTHUMP00000115709,brain-cadherin,cadherin 12, type 2,cadherin, neural type, 2,cadherin-12,neuronal cadherin 2